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But they activate receptors differently

However, the earlier phase 2 NASH trial did not show a significant fibrosis benefit, and semaglutide is not yet approved for MASH

( In fact, BMI may not be the best or even a good parameter for defining risk related to body composition, as it is poor at discriminating the ratio of fat to lean tissue within body weight

Sofogianni A, Filippidis A, Chrysavgis L, Tziomalos K, Cholongitas E

Participants in clinical trials who combined tirzepatide with behavioral modifications lost more weight than those relying solely on the injection

However, when significant health problems are driven by weight, we aim for a lower goal and discuss the health problems as well. Options for patients who are not reaching their target At a certain point, patients often reach their personal maximum dose (or dosing maximum) and may still not have lost enough weight to be in a healthier place