semaglutide joint pain relief May Reverse Damage Caused by Osteoarthritis, Study Suggests : ScienceAlert GLP-1 Inhibitor Reduces Knee Osteoarthritis

doi: 10.3389/fcvm.2025.1731127 Received 23 October 2025 Revised 15 November 2025 Accepted 28 November 2025 Published 15 December 2025 Volume 12 - 2025 Edited by Manfredi Tesauro, University of Rome Tor Vergata, Italy Reviewed by Angelo Maria Patti, University of Palermo, Italy Antonio Maria Labate, ASST Franciacorta, Italy Updates Copyright 2025 Tan, Yin and Lu

Compounded versions of injectable semaglutide are available from compounding pharmacies, but these have not been tested by or approved by the FDA

approved final version of manuscript

Common side effects include nausea, constipation, vomiting, and appetite suppressionmost are mild and improve after the first few weeks as your body adapts

Compounded semaglutide from a state-licensed 503A pharmacy is legal in every state under these rules

Any larger drops in the first few weeks are predominantly water, glycogen depletion, and reduced food volume in the digestive tract