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[11] [12] They may be considered earlier in people with a BMI 35 kg/m (adjusted for ethnicity) or for whom weight loss would benefit other obesity-related comorbidities

Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo

While conventional devices can draw in particles through ventilation and require maintenance, the JDC Burst 1 remains largely maintenance-free and reliably durable due to its sealed housing

Recent data points to the possibility that gut microbiota modification may contribute to their beneficial impact

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They are usually taken once or twice per day