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Within the hypothalamus, Gipr- expressing cells are localized in the paraventricular, dorsomedial and arcuate nuclei and colocalize with markers for neurons, glia and vascular cells

This is due to reduced circulation of blood to the optic nerve, which causes the nerve to swell and sustain damage disrupting the ability of the eye to send information to the brain

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A second paper, published in 1987, was a landmark: The tests showed that GLP-1 led to insulin secretion