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retatrutide triple agonist glp-1 gip glucagon phase 2 nejm 2023 Structural insights into the agonism at GLP-1R, GIPR and GCGR manifested by retatrutide peptide | peptidesskin
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Nausea was often reported during dose escalation, with 1017% 6 of participants discontinuing treatment across dose cohorts due to GI symptoms

H.RudolphR.et al (2010)
Weight loss with GLP-1 medications is generally steady and sustainable rather than rapid

people consistently report these GI symptoms, and they rarely report other symptoms, he says

Note: If you have pre-existing kidney issues or are on blood pressure medication, always consult your healthcare provider before significantly increasing your intake of potassium or sodium
