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Intranasal drug delivery This approach constitutes a potential alternative method for therapeutic brain targeting and is based on the direct transport into the CSF enabled by the presence of the neural pathways connecting the nasal mucosa and the brain [38]
10.1016/j.bcp.2024.116471 44 LeeY
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By rigorously evaluating the statistical considerations and robustness of TTE analysis, researchers can strengthen the evidence base for this approach and ensure its appropriate application in clinical trials for PD and other neurodegenerative diseases

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