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Structure-Function of the Glucagon Receptor Family of G Protein-Coupled Receptors: The Glucagon, GIP, GLP-1, and GLP-2 Receptors

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Shawn Xiong, PhD Study details: GLP-1 drugs and Alzheimers disease To accomplish the research on a larger scale, Xiong is using a method called target trial emulation

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Curr Obes Rep 14 , 34 (2025)

However, GLP-1 is proteolytically cleaved by dipeptidyl peptidase 4 (DPP-4), resulting in a plasma half-life of 2 minutes, which limits its therapeutic efficacy in patients with T2DM