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TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice

UPS dysregulation occurs in the ageing process and several ageing-related diseases in mammals, and this proteostasis system failure accelerates the accumulation of misfolded proteins and aggregation of damaged organelles [195]

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have reported that GLP-1/exendin-4 could ameliorate oxidative stress-induced injury in PC12 cells (182)

Circ Cardiovasc Interv 2012;5:288295
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Its foundational