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Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis

Methods We selected individuals aged 45 years and older already treated with metformin living in Lombardy, Italy, and then split them into two groups if they initiated GLP-1 RAs or other antidiabetic drugs, between 2019 and 2021

Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder characterized by insulin resistance and impaired ?-cell function

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The company plans to file for US and EU label expansions to include this pediatric population, using the oral version of its GLP-1 therapy already sold as Rybelsus