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Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability

6 It works by interfering with the process that creates adenosine triphosphate (ATP)

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doi: 10.1038/nrendo.2015.216

The most prescribed GLP-1RA was semaglutide 1 mg (33%), followed by tirzepatide 7.5 mg (25%)

When Microdosing May Not Be Appropriate Microdosing is not appropriate when core safety or metabolic foundations have not been addressed