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The potential for weight loss is interesting, but I think the most interesting reason to pursue glucagon agonism in a multi-receptor agonist is the possibility that you could alter hepatic liver metabolism and potentially decrease fatty acid accumulation and hypertriglyceridemia.

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Complete weight regain occurred in only 23% of semaglutide users at 24 months

November 22, 2024: Scientists Push For Increased Research About Cancer Risks for Wegovy and Other GLP-1 Drugs The journal Endocrine Connections published a study called Glucagon-like peptide 1 receptor agonists and thyroid cancer: is it the time to be concerned? where scientists examined how long-term GLP-1 use might increase someones risk of developing thyroid cancer