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Ananthanarayanan M, Balasubramanian N, Makishima M, et al

40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption

However, when administered during reperfusion, both GLP-1 (7-36amide) and GLP-1 (9-36amide) improve functional recovery from I/R injury in both WT and GLP-1R KO mice [201]

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It has the largest rotation surface area and a consistent subcutaneous fat layer

1 Wilding JPH, et al