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Zepbound (tirzepatide) has produced the greatest weight-loss results in clinical trials, followed by Wegovy (semaglutide)

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Gatto, A., Liu, K., Milan, N., & Wong, S

For people with clinical obesity, the kind that's harming their health, Kushner's message is close to unequivocal: they work, they're disease-modifying, and the lifelong framing is a feature, not a bug

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Furthermore, a cohort study revealed that the majority of patients experienced a remarkable 5-10% reduction in weight after six months, with some achieving an astounding 20% or more