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DISCUSSION Our project had some significant limitations due to the study design

Although the achieved level of glycemic control differed between groups (7.8% vs 8.2%), this small difference seems unlikely to fully account for identified benefits

Tirzepatide produced greater A1c reductions in the SURPASS-2 head-to-head trial, making it the stronger option for glucose control

The GI side effects that plague so many semaglutide users, the nausea, the bloating , the constipation, the diarrhea, are not random bad luck

In one study of persons taking semaglutide, users regained up to two-thirds of the weight lost within six months of discontinuing the medication

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