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Exendin-4 did not affect the ability of cocaine to attenuate dopamine uptake, which suggests that GLP-1 receptor activation exerts its suppressive effects on cocaine-induced dopamine release in the accumbens core by reducing the excitability of midbrain dopamine neurons [151]

First, we found that neurogenesis derived from cells born during TAM was not substantially affected by TAM injection

It is important to distinguish between side effects directly attributable to the medication's pharmacological action and those arising from the broader context of weight management

2010 Dec;11(12):1803-18

Registered trial records list the study sponsor, locations, eligibility criteria, study design, and contact routes

Discussion The present study demonstrates that the long-acting GLP-1R agonist semaglutide suppresses voluntary wheel running behavior in both lean and DIO mice, revealing a previously underappreciated influence of GLP-1 signaling on non-ingestive motivated behaviors