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This high cost, along with limited manufacturing supply, means usage has remained mostly concentrated in wealthier countries (notably the US and parts of Europe) and among patients who can afford to pay

References: Malhotra A, Grunstein RR, Fietze I, et al

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There is no established washout protocol for switching between these drugs yet

Taher J, Baker CL, Cuizon C, Masoudpour H, Zhang R, Farr S, et al

Its two sides