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51.Cardiovascular risk reduction with liraglutide: an exploratory mediation analysis of the LEADER trial

So far, the mechanisms underlying the protective effects of GLP-1RA in respiratory disease are not fully understood

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Since GLP-1 is prone to degradation by dipeptidyl peptidase 4, GLP-1 receptor agonists (GLP-1RAs) have been developed to surmount this degradation challenge

Considering these immunomodulatory and anti-inflammatory effects, GLP-1RAs are being investigated for their potential in treating inflammation-associated diseases

Sally Seymour, director of the Division of Pulmonology, Allergy, and Critical Care in the FDAs Center for Drug Evaluation and Research, said in a news release