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[DOI] [PMC free article] [PubMed] [Google Scholar] [132].Filippatos TD, Panagiotopoulou TV, Elisaf MS

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It works by activating two key hormone receptors: GLP-1 receptors GIP receptors These pathways help regulate: Appetite Blood sugar levels Insulin response Energy balance Its long half-life allows for steady hormone signaling without daily dosing

Anhedonia and Depression on GLP-1s Because GLP-1s dampen dopamine release, there is a risk of dopamine blunting. This happens when the body doesnt release enough dopamine and causes emotional flatness