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Common Side Effects Both medications cause primarily gastrointestinal effects: Saxenda common side effects: Nausea (39%) Diarrhea (21%) Constipation (19%) Vomiting (16%) Injection site reactions (14%) Headache (14%) Dyspepsia (10%) Semaglutide common side effects: Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (24%) Abdominal pain (20%) Headache (14%) Fatigue (11%) Side Effect Comparison Table Interpreting the Numbers Semaglutide appears to have higher rates of GI side effects in clinical trials

In food-induced glucose-intolerant and prediabetic cynomolgus monkeys, oral administration of RGT-075 improved glucose tolerance and reduced food intake and fasting glucose levels

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