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PF-07976016 - oral GIPR antagonist Phase 2

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in patients with knee osteoarthritis and type 2 diabetes if treatment is sustained for a sufficient period, according to data.The researchers, who published their findings in the Annals of the Rheumatic Diseases, added that the result may be mediated by weight loss.

The findings suggest that providers are largely following recommended dosing schedules designed to improve tolerability as oral GLP-1 therapies continue to gain traction in obesity treatment

(Theres always a "but", isn't there?) Heres whats actually changing: Patients on semaglutide lose fat everywhere, including the face

Currently, there are ten classes of orally available pharmacological agents to treat T2DM: 1) sulfonylureas, 2) meglitinides, 3) metformin (a biguanide), 4) thiazolidinediones (TZDs), 5) alpha glucosidase inhibitors, 6) dipeptidyl peptidase IV (DPP-4) inhibitors, 7) bile acid sequestrants, 8) dopamine agonists, 9) sodium-glucose transport protein 2 (SGLT2) inhibitors and 10) oral glucagon like peptide 1 (GLP-1) receptor agonists