diabetes management algorithm step 2 medicine shelf glyburide semaglutide 2·4 mg once a week in adults with overweight or obesity, and type (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial Type 2 diabetes treatment guidelines

A newer form of semaglutide (Rybelsus) is available as a daily tablet, but is not yet available in SA

In another study, Mounjaro (tirzepatide) was associated with reduced left ventricular mass and less fat surrounding the heart in patients with obesity-related heart failure

CSF A42 predicts early-onset dementia in Parkinson disease

Consistent with systemic exendin-4 dose-response studies, the dose of intra-VTA exendin-4 (0.05 g) used in these studies reduced cocaine seeking and did not affect ad libitum chow intake or promote malaise-like effects in rats [67, 110, 131]

New England Journal of Medicine , 378(25), e34

However, when the drug stops and appetite returns, it seems that those strategies are not sufficient to enable people to continue to manage their weight, she said