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Periprostatic adipose tissue, which is part of the surrounding microenvironment for prostate cancer, participates in bidirectional interplay with cancer cells via the paracrine route [38]

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In controlled clinical studies as both monotherapy and combination therapy with metformin, pioglitazone, or rosiglitazone and metformin, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo

doi: 10.2337/dci24-0003 46 RavenMLGreenfieldRJMuirAC

Obesity induces metabolic disturbances in adipose tissue, influencing the release of hormones, adipokines, inflammatory cytokines, growth factors, enzymes, and free fatty acids [12]

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