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SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), significant on 4-point MACE (0.88) and all-cause death (0.84): Heerspink SURPASS-4 kidney post-hoc

A study conducted in March 2025 involving 350,000 patients found that two years of Ozempic use more than doubled the risk of developing the condition compared to alternative diabetes treatments

Lancet 387:679690 Wang H, Wang L, Cheng Y et al (2018) Efficacy of Orlistat in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Each condition has distinct pathophysiology, which means any medication relevance must be evaluated condition by condition, not as a blanket statement about "autoimmune disease." Where does tirzepatide fit in this landscape

Anti-inflammatory M2 macrophages are activated by Th2 cytokines, produce signals that promote tissue repair, and actively suppress inflammation ( Macrophage On and Off-Targets and Responses It has been shown that GPER and ER do not mediate the off-target macrophage responses to tamoxifen, since macrophages do not express ER and GPER-selective activation elicits different responses as those induced by tamoxifen