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GLP-1 drugs, such as semaglutide and tirzepatide, used for diabetes and weight loss, may also reduce knee osteoarthritis pain and delay knee replacement surgery

The work of Lebrun et al now adds an important piece to this puzzle by describing a critical and previously unrecognized role for the gut-derived hormone glucagon-like-peptide 1 (GLP-1) in the regulation of intestinal inflammation

But for many appropriate patients, the benefits of treating obesity far outweigh the risks of doing nothing