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Whereas both exendin-4 and GLP-1 were found to bind to the same site in the receptor, the crystal structures alone did not adequately explain the reason why exendin-4 has a higher affinity to the isolated NTD of GLP-1R compared to GLP-1

Crosstalk between gut microbiota and antidiabetic drug action

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A strength drop is not automatically a direct drug effect

Stick to your prescribed injection schedule
