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All animal experiments were conducted using male mice and approved by the Institutional Animal Care and Use Committee of Shonan Research Center (AU-00040058)

10.3389/fphar.2024.1378371 28 RouxS.CherradiS.DuongH

On the contrary, we decided to exclude chirality or atomic mass features, as we hypothesized these factors have minimal influence on pKa prediction

This is shown by the fact that no governmental or international organization requires bottled water producers or municipal systems to comply with predetermined pH levels

The consistency across dose groups is telling

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