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doi: 10.1210/en.2016-1334

Head-to-head trials showed tirzepatide achieves approximately double the weight loss of semaglutide and brings 46 percent of diabetic patients to a normal HbA1c below 5.7 percent versus 19 percent with semaglutide

Long-term weight outcome (208 weeks): mean reduction of 10.2% versus 1.5% with placebo

Whether youre managing type 2 diabetes or struggling with weight loss, you may have heard of medications like Ozempic, Wegovy, or Mounjaro

For more on how side effects can shift early in treatment, see our semaglutide side effects guide
Yabe, D., & Seino, Y