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We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity

Semaglutide, the active ingredient in well known injectables like Ozempic and Wegovy, works by mimicking GLP-1, a hormone that helps regulate blood sugar, curb cravings, and promote steady weight loss.

Which wins for T2D control?

Julie Weber, director of the Missouri Poison Center, said it got 28 calls related to semaglutide in 2021

Among these effects, increased insulin sensitivity, either by direct action on target organs or secondary to weight loss, might act synergistically with enhanced beta-cell function and insulin upregulation in the pancreas, collectively improving metabolic control.