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Description
These agents mimic the action of endogenous GLP-1, an incretin hormone released from intestinal L-cells in response to nutrient intake

These mechanisms operate independently, meaning TRT does not directly interfere with GLP-1 efficacy, and vice versa

Biol Reprod (2021) 105(2):37180

Unlike semaglutide, tirzepatide is a dual receptor agonist targeting both GLP1R and GIPR

Brain insulin resistance is an important pathogenetic feature of AD and is mediated primarily by impaired insulin signaling (Sdzikowska and Szablewski, 2021)

He is currently affiliated with the world-renowned NY Presbyterian/Weill Cornell Medical Center