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The best available data show that both semaglutide and tirzepatide reduce fat mass substantially and lean mass to a lesser extent, roughly in proportion to total weight lost

Its needed to make protein, bones and DNA

The apparent absence of the bone mineral density preservation effect seen with liraglutide in MC4R -deficient patients, unlike in common obesity, underscores the need for vigilant bone health assessment and potential adjunctive interventions in this group

Early appetite and tolerability effects may appear in the first few weeks, but clinical-trial efficacy is better judged at longer endpoints

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Shimizu, I., Hirota, M., Ohboshi, C