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Their study confirmed GLP-1s increased the risk of nausea, vomiting, kidney stones, sleep disturbances and other gastrointestinal problems

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Patients should also disclose all current medications and supplements, as tirzepatide may affect the absorption of some oral medications due to delayed gastric emptying

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Retatrutide appeared to induce lean mass loss in similar proportions to GLP-1RAs alone, whereas PTT-A has shown robust fat reduction without significant decrease in muscle mass, highlighting the potential of selective multi-agonists to preserve skeletal muscle during weight loss [66, 67]