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Survodutides More Moderated Appetite Effect Survodutide still engages GLP-1 signaling, but its dual agonist design balances appetite regulation with glucagon-mediated metabolic activity

As we did not observe any discontinuation of treatment during the study period, it remains unclear whether pwIIH successfully treated with GLP-1-RAs sustain their weight loss, or a yo-yo effect occurs [44], which would pose an increased risk for a disease relapse

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and W.-H.H

A study from the University of British Columbia found a more than twofold higher risk in women on semaglutide (adjusted hazard ratio 2.08)