asa guidelines for glp 1 agonists Perioperative management of patients taking glucagon-like peptide-1 receptor agonists: a restrictive fasting regimen is not necessary. Comment on Br J Anaesth 2025; 135: 48–78 GLP1 agonists: current and future

More serious concerns include a possible increased risk of pancreatitis (inflammation of the pancreas) and, in animal studies, thyroid C-cell tumors

- Trial timelines will stretch, delaying access to proven therapies

GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum

[DOI] [PubMed] [Google Scholar] 144.Dubois-Laforgue D, Boutboul D, Levy DJ, Joly D, Timsit J

But food companies are trying to convince consumers to buy their products as a convenient alternative and believe it is a necessity, which it is not

When properly compounded from pharmaceutical-grade ingredients, effectiveness is equivalent at 67% lower cost ($349 vs $1,069/month)