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thus, it may induce hypoglycemia and it is contraindicated in patients with advanced liver insufficiency.66 In contrast, the pharmacodynamics of nateglinide is not altered in patients with CLD and is thus expected to be safer.67 Incretin-based therapies Incretin-based therapies comprise injectable glucagon-like peptide-1 (GLP-1) receptor agonists and oral inhibitors of dipeptidylpeptidase-4 (DPP-4)(gliptins)

By targeting appetite and metabolic regulation, the treatment helps many patients reduce food intake and achieve meaningful weight loss

doi:10.1056/NEJMoa2032183 Wharton S, et al

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Excess Belly and Visceral Fat Excess belly and visceral fat pose significant health risks, including heart disease, liver disease, and diabetes

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