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These include uncontrolled diabetes, active infections, a history of HIV/AIDS or Hepatitis B/C (permanent disqualification), certain severe heart or lung diseases, certain autoimmune disorders, and a history of specific types of organ or tissue transplants

Connective tissue disorders: Illnesses such as scleroderma can influence stomach muscle function

As most RCTs were designed to evaluate metabolic or cardiovascular outcomes rather than cancer endpoints, their follow-up periods may be insufficient to fully capture the latency of solid tumor development

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An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases
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