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Interestingly, the STEP-8 study 22 revealed a higher incidence of psychiatric events with liraglutide 3 mg (15.0%) compared to semaglutide 2.4 mg (5.6%) and placebo (10.6%)

Weight loss from Mounjaro may indirectly influence hormonal systems, but this represents an effect of weight reduction rather than direct pharmacological action on adrenal glands

Our aim is to briefly review the weight-related results reported in the context of cardiovascular outcomes trials (CVOTs) and discuss the possible implications for clinical practice

The patterns were concerning

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