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Thyroid C-Cell Tumors: In mice and rats, tirzepatide (the active ingredient in Zepbound and Mounjaro) caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

Ozempic Safety Timeline: FDA Warnings, Studies, And Lawsuits December 2025: Multidistrict litigation was formed for claims that Ozempic caused patients to develop NAION (non-arteritic anterior ischemic optic neuropathy)

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But not all of it is safe, pure, or even actually retatrutide

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For the receptor chain A, no new mutation design was performed