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Description

A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37) Journal of Biological Chemistry

Their smaller molecular structure also facilitates better tissue penetration and lower production costs, which could enhance accessibility to these novel medications

GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent mannermeaning they only promote insulin release when blood glucose levels are elevated, which significantly reduces the risk of hypoglycaemia compared with some other diabetes medicines

Originally approved in 2005 Trusted Source PubMed Central Go to source , GLP-1 analogs produced significant and beneficial weight loss in type 2 diabetes patients