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Administration of liraglutide to normal and diabetic mice before inducing MI reduced cardiac rupture and infarct size, improved cardiac output, and modulated the expression of cardioprotective genes in the mouse heart, including Akt, GSK-3beta, PPARbeta-delta, NRF-2, and HO-1

Structural figures were prepared using UCSF Chimera 49 and PyMOL (The PyMOL Molecular Graphics System v.2.1)

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Pre-treatment with 10 M compound C significantly decreased the sub-G1 fraction in cells incubated with MG (Fig

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