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Hard-to-control hypertension is often driven by aldosterone dysregulation

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A 2025 Cochrane review of 18 studies confirmed that semaglutide (Wegovy/Ozempic) results in approximately 10.7% greater weight loss compared to placebo, with high-certainty evidence [6]

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Progesterone influences sleep quality, sleep disruption can increase cortisol levels, and elevated cortisol may amplify side effects such as nausea or digestive discomfort