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Certain populations should avoid GLP-1 probiotic supplements or use them only under close medical supervision due to elevated risk of adverse outcomes

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The REWIND trial , 26 in an exploratory analysis, similarly showed that patients receiving dulaglutide had a relative risk reduction of 15% (NNT 167) in the composite renal outcome and 23% in new macro-albuminuria compared with placebo

63 A case series linked the use of semaglutide or tirzepatide with an increased risk of NAION, sometimes after a single dose, including in one patient without diabetes and in another who experienced symptoms in both eyes following separate doses

Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, et al