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Given that the mGIPR-Ab/GLP-1 peptideantibody conjugate probably accesses the brain through CVOs, with the highest concentration in the AP, Gipr and Glp1r mRNA were measured in the mouse AP

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Saffron at high doses has been associated with GI upset in some people, though the doses used in these studies werent flagged for safety concerns

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However, the CeA, a brain region essential for the initiation of the stress response [166], appears critical for generating the anxiogenic effects of GLP-1 since the administration of the peptide in CeA does not modify plasma corticosterone levels but decreases the time spent in the open arms of the EMP [120]