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Greater insulinotropic action of oral glucose relative to its peripheral administration was demonstrated for both normal weight and obese individuals [63] and henceforth became known as the incretin effect [64,65]

nonetheless, significant factors must be considered for patient selection and monitoring

North America is one of the markets showing steady growth in oral GLP-1 agonists owing to the high prevalence of the disease and early adoption of newer drugs

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As a precaution, the FDA warns patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid using Zepbound (Tirzepatide)