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doi: 10.1136/rapm-2023-104751

Mounjaro is unique in that it acts on both the GIP and GLP-1 receptors

results are aligned with ours revealing that BMI reductions that were seen (1.147 kg/m 2 at 24 months) indicate that GLP-1 RA weight loss effects contribute to therapeutic advantages by reducing intracranial venous pressure and decreasing the generation of pro-inflammatory adipokines
It does this by activating multiple arousal systems simultaneously: the noradrenaline system, the histamine system, the dopamine system, and the serotonin system
[15] [16] Clinical studies examining the effects of GLP-1 receptor agonists on resting metabolic rate (RMR) and total energy expenditure have produced consistent findings: these medications do not significantly increase metabolic rate
