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Weight loss drugs are big business, with the GLP-1 receptor agonist market expected to nearly triple in size to $185 billion by 2033, a compound annual growth rate of about 12.4%

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Besides, GIPR has a relatively larger conformational difference between tirzepatide-bound and non-acylated tirzepatide-bound structures in most regions compared with GLP-1R (Supplementary Fig

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