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However, the patient population was overwhelmingly white (88%), thus failing to represent ethnic minorities who have greater prevalence of diabetes in Canada

In patients with type 2 diabetes inadequately controlled on metformin alone, the overall incidence of adverse reactions of hypoglycemia was 1.3% in patients given add-on sitagliptin and 2.1% in patients given add-on placebo

Hurley stage III, the most severe, is characterised by extensive irreversible tissue damages, advanced pervasive fibrosis, multiplication of sinus tracts and extension of scarring across the entire anatomical region [78] (Fig

6c,d and Extended Data Fig

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