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Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation: a phase 3, randomized, placebo-controlled study

The prevalence of bullous pemphigoid was 0.0859% in total, with a trend toward a higher risk associated with vildagliptin use compared to the other DPP-4 inhibitors ( In total, however, the DPP-4 inhibitor class has demonstrated a good safety and tolerability spectrum that justifies the wide use of the class

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Thus, a shift toward increased clinical utility is influencing the industry competition in favor of GLP-1 receptor agonists and attracting investments into research and development projects aimed at improving therapeutic options

Walid Gellad, a professor of medicine at the University of Pittsburgh who studies medication adherence