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GLP-1 drugs do the same

The bupropion component carries an FDA boxed warning for increased suicidal ideation in young adults, similar to other antidepressants

Data availability All data generated or analyzed during this study are included in this published article

Even a modest weight loss of 5% has been shown to improve cardiometabolic risk factors, including reduced systolic blood pressure and plasma triglyceride concentration, and increased multi-organ insulin sensitivity and -cell function [6]

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10.1016/j.nano.2016.08.004 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Melgar S, Karlsson L, Rehnstrm E, Karlsson A, Utkovic H, Jansson L, Michalsson E