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This metric quantifies the minimum strength of association that an unmeasured confounder would need to have with both the exposure and outcome to nullify the observed effect, with larger values suggesting greater robustness to potential unmeasured confounding

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The risks simply outweigh any potential benefits in these groups, and alternative treatments should be explored instead

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But slower digestion upstream means less material reaching your colon, and your colon needs bulk to trigger the contractions that produce a bowel movement