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One critical but often overlooked contributor is excess body weight, which can disrupt the delicate balance of reproductive hormones such as testosterone, follicle-stimulating hormone, and luteinizing hormone

Most patients notice appetite suppression within the first 2-3 weeks, but measurable weight loss typically appears after 4-8 weeks as doses reach therapeutic levels
10.1161/CIRCULATIONAHA.122.059595 3

Also GLP1RAs have been found to decrease epicardial fat, which may help explain their potential in lowering the risk of atherosclerosis

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